10 citations · 20 across the 17 of their papers we have counts for
4 papers · 1 filter
A Novel Statistical Test for Treatment Differences in Clinical Trials using a Response Adaptive Forward Looking Gittins Index Rule
Helen Yvette Barnett, Sofia S Villar, Helena Geys +1
The most common objective for response adaptive clinical trials is to seek to ensure that patients within a trial have a high chance of receiving the best treatment available by al…
Adding flexibility to clinical trial designs: an example-based guide to the practical use of adaptive designs
Thomas Burnett, Pavel Mozgunov, Philip Pallmann +3
Adaptive designs for clinical trials permit alterations to a study in response to accumulating data in order to make trials more flexible, ethical and efficient. These benefits are…
Learning for Dose Allocation in Adaptive Clinical Trials with Safety Constraints
Cong Shen, Zhiyang Wang, Sofia S. Villar +1
Phase I dose-finding trials are increasingly challenging as the relationship between efficacy and toxicity of new compounds (or combination of them) becomes more complex. Despite t…
Response-adaptive randomization in clinical trials: from myths to practical considerations
David S. Robertson, Kim May Lee, Boryana C. Lopez-Kolkovska +1
Response-Adaptive Randomization (RAR) is part of a wider class of data-dependent sampling algorithms, for which clinical trials are typically used as a motivating application. In t…