6 citations · 8 across the 13 of their papers we have counts for
6 papers · 1 filter
Introducing precision-weighted bias as a performance measure to inform the inclusion of adaptive designs in meta-analysis
Martin Law, David S. Robertson, Sofia S. Villar +4
We propose a novel, intuitive measure of statistical performance: precision-weighted bias. Precision-weighted bias is defined as the unconditional bias of an estimator weighted by…
Beyond the Composite: Enhancing Trial Analysis through a Divide & Conquer Approach to 'Days Alive and at Home': Insights from the NOTACS trial
Letao Yuan, Sofía S. Villar, Dominique-Laurent Couturier
"Days alive and at home" (DAH) is a recent patient-centered outcome measure for perioperative trials, defined as the number of days a patient spends at home during the follow-up pe…
Component over Composite: Mitigating Type I Error Inflation when Imputing "Days Alive and at Home"
Mia S. Tackney, Sarah Dawson, Letao Yuan +2
Background: Days Alive and at Home (DAH) over a pre-defined follow-up period is a novel post-intervention composite outcome that combines data from at least three components: (i) i…
Operationalizing Allocation Probability Tests: Practical Guidance on Optimized Implementation for Power and Robustness
Stina Zetterstrom, David S. Robertson, Thomas Jaki +1
Recently, a new testing approach for response-adaptive clinical trials was proposed based on the allocation probabilities (AP) rather than the outcome data. While original work on…
Exact statistical analysis for response-adaptive clinical trials: A general and computationally tractable approach
Stef Baas, Peter Jacko, Sofía S. Villar
Response-adaptive clinical trial designs allow targeting a given objective by skewing the allocation of participants to treatments based on observed outcomes. Response-adaptive des…
A Novel Statistical Test for Treatment Differences in Clinical Trials using a Response Adaptive Forward Looking Gittins Index Rule
Helen Yvette Barnett, Sofia S Villar, Helena Geys +1
The most common objective for response adaptive clinical trials is to seek to ensure that patients within a trial have a high chance of receiving the best treatment available by al…