24 citations · 63 across the 19 of their papers we have counts for
21 papers
Dark energy: the cost of function in protein evolution
Ezequiel A. Galpern, Federico Caamaño, Ignacio E. Sánchez +1
The evolutionary fate of proteins is driven by both folding stability and biological function, dual constraints that often conflict, creating frustration and imposing functional co…
Probing the Dark Energy in the Functional Protein Universe
Ezequiel A. Galpern, Carlos Bueno, Ignacio E. Sánchez +2
We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the ene…
Predicting protein folding dynamics using sequence information
Ezequiel A. Galpern, Federico Caamaño, Diego U. Ferreiro
Natural protein sequences somehow encode the structural forms that these molecules adopt. Recent developments in structure-prediction are agnostic to the mechanisms by which protei…
Frustration, dynamics and catalysis
R. Gonzalo Parra, Diego U. Ferreiro
The controlled dissipation of chemical potentials is the fundamental way cells make a living. Enzyme-mediated catalysis allows the various transformations to proceed at biologicall…
Frustration In Physiology And Molecular Medicine
R. Gonzalo Parra, Elizabeth A. Komives, Peter G. Wolynes +1
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and per…
Inferring protein folding mechanisms from natural sequence diversity
Ezequiel A. Galpern, Ernesto A. Roman, Diego U. Ferreiro
Protein sequences serve as a natural record of the evolutionary constraints that shape their functional structures. We show that it is possible to use only sequence information to…