6 papers
Frustration, dynamics and catalysis
R. Gonzalo Parra, Diego U. Ferreiro
The controlled dissipation of chemical potentials is the fundamental way cells make a living. Enzyme-mediated catalysis allows the various transformations to proceed at biologicall…
Frustration In Physiology And Molecular Medicine
R. Gonzalo Parra, Elizabeth A. Komives, Peter G. Wolynes +1
Molecules provide the ultimate language in terms of which physiology and pathology must be understood. Myriads of proteins participate in elaborate networks of interactions and per…
Inferring repeat protein energetics from evolutionary information
Rocío Espada, R. Gonzalo Parra, Thierry Mora +2
Natural protein sequences contain a record of their history. A common constraint in a given protein family is the ability to fold to specific structures, and it has been shown poss…
Protein Repeats from First Principles
Pablo Turjanski, R. Gonzalo Parra, Rocío Espada +2
Some natural proteins display recurrent structural patterns. Despite being highly similar at the tertiary structure level, repetitions within a single repeat protein can be extreme…
Capturing coevolutionary signals in repeat proteins
Rocío Espada, R. Gonzalo Parra, Thierry Mora +2
The analysis of correlations of amino acid occurrences in globular proteins has led to the development of statistical tools that can identify native contacts -- portions of the cha…
Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space
R. Gonzalo Parra, Rocío Espada, Ignacio E. Sánchez +2
The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easi…