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cs.LG2026
AutoNovo: Agentic Program Search Discovers Transferable Nucleic Acid Design Algorithms
Joel Shor, Subhashini Venugopalan
In-silico optimization of nucleic acids relies on predictive oracles that imperfectly capture biological function, so sequences optimized against one model may exploit model-specif…
cs.LG2026
From DNA Design to DNA Slimming: Auditable Agentic Discovery of a Deletion-Only Designer
Joel Shor
Compact regulatory DNA can free up space in vector payloads, reduce synthesis and assay burden, and expose which sequence features drive predicted activity. Yet most model-based nu…