906 citations · 1.1k across the 3 of their papers we have counts for
3 papers
The relation between alignment covariance and background-averaged epistasis
Frank J. Poelwijk, Rama Ranganathan
Epistasis, or the context-dependence of the effects of mutations, limits our ability to predict the functional impact of combinations of mutations, and ultimately our ability to pr…
Quantification of the effect of mutations using a global probability model of natural sequence variation
Thomas A. Hopf, John B. Ingraham, Frank J. Poelwijk +3
Modern biomedicine is challenged to predict the effects of genetic variation. Systematic functional assays of point mutants of proteins have provided valuable empirical information…
The context-dependence of mutations: a linkage of formalisms
Frank J. Poelwijk, Vinod Krishna, Rama Ranganathan
Defining the extent of epistasis - the non-independence of the effects of mutations - is essential for understanding the relationship of genotype, phenotype, and fitness in biologi…