4 papers
TriGlue: a Biology-Inspired Generative Model for Generating Molecular Glue-Induced Ternary Complex
Yuliang Yan, Shuo Yan, Haochun Tang +2
Molecular glue degraders have emerged as a promising strategy for targeted protein degradation by inducing ternary complex formation between an E3 ubiquitin ligase and a target pro…
General Protein Pretraining or Domain-Specific Designs? Benchmarking Protein Modeling on Realistic Applications
Shuo Yan, Yuliang Yan, Bin Ma +6
Recently, extensive deep learning architectures and pretraining strategies have been explored to support downstream protein applications. Additionally, domain-specific models incor…
UniZyme: A Unified Protein Cleavage Site Predictor Enhanced with Enzyme Active-Site Knowledge
Chenao Li, Shuo Yan, Enyan Dai
Enzyme-catalyzed protein cleavage is essential for many biological functions. Accurate prediction of cleavage sites can facilitate various applications such as drug development, en…
DuFFin: A Dual-Level Fingerprinting Framework for LLMs IP Protection
Yuliang Yan, Haochun Tang, Shuo Yan +1
Large language models (LLMs) are considered valuable Intellectual Properties (IP) for legitimate owners due to the enormous computational cost of training. It is crucial to protect…