4 papers
Advanced Characterization Methods for Crystals of an Extraordinary Material
Vivekananda Bal, Jackie M. Wolfrum, Paul W. Barone +4
Physicochemical characterization of materials is central to the field of science and engineering and is essential to design new/engineered materials with specific properties. Assay…
A Phase Diagram for Crystallization of a Complex Macromolecular Assembly
Vivekananda Bal, Jacqueline M. Wolfrum, Paul W. Barone +4
Crystallization of biological molecules has high potential to solve some challenges in drug manufacturing. Thus, understanding the process is critical to efficiently adapting cryst…
An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics
Vivekananda Bal, Moo Sun Hong, Jacqueline M. Wolfrum +5
Crystallization of proteins, specifically proteins of medical relevance, is performed for various reasons such as to understand the protein structure and to design therapies. Obtai…
Selective Enrichment of Full AAV Capsids
Vivekananda Bal, Jacqueline M. Wolfrum, Paul W. Barone +4
Gene therapies using recombinant adeno-associated virus (rAAV) have been developed to treat monogenic and acquired diseases but are currently the most expensive drugs due, in part,…