4 papers
Large Language Models Meet Virtual Cell: A Survey
Krinos Li, Xianglu Xiao, Shenglong Deng +7
Large language models (LLMs) are transforming cellular biology by enabling the development of "virtual cells"--computational systems that represent, predict, and reason about cellu…
Accurate and generalizable protein-ligand binding affinity prediction with geometric deep learning
Krinos Li, Xianglu Xiao, Zijun Zhong +1
Protein-ligand binding complexes are ubiquitous and essential to life. Protein-ligand binding affinity prediction (PLA) quantifies the binding strength between ligands and proteins…
Artificial Immunofluorescence in a Flash: Rapid Synthetic Imaging from Brightfield Through Residual Diffusion
Xiaodan Xing, Chunling Tang, Siofra Murdoch +10
Immunofluorescent (IF) imaging is crucial for visualizing biomarker expressions, cell morphology and assessing the effects of drug treatments on sub-cellular components. IF imaging…
Can Generative AI Replace Immunofluorescent Staining Processes? A Comparison Study of Synthetically Generated CellPainting Images from Brightfield
Xiaodan Xing, Siofra Murdoch, Chunling Tang +7
Cell imaging assays utilizing fluorescence stains are essential for observing sub-cellular organelles and their responses to perturbations. Immunofluorescent staining process is ro…