12 papers · 1 filter
Circulating Lymphocytes Preservation in Lung Cancer Stereotactic Body Radiation Therapy with Ultra-Fast Proton Delivery Using Modularized Pin Ridge Filters
Duncan Bohannon, Ahmal Jawad Zafar, Sibo Tian +9
Purpose: Radiation-induced lymphopenia is an increasingly recognized toxicity in lung radiotherapy and has been linked to radiation exposure to circulating lymphocytes (CL). In int…
A Digital Twin Framework for Adaptive Treatment Planning in Radiotherapy
Chih-Wei Chang, Sri Sai Akkineni, Mingzhe Hu +7
The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostati…
Optimizing Transmission FLASH Radiotherapy for Large-Field Post-Mastectomy Breast Treatment
Ahmal Jawad Zafar, Sunil William Dutta, Matthew Joseph Case +5
We investigated the effects of scanning speed, beam configuration, and dose-rate modeling on the FLASH effect in post-mastectomy proton transmission-beam (TB) planning and evaluate…
Patient-Specific Deep Reinforcement Learning for Automatic Replanning in Head-and-Neck Cancer Proton Therapy
Malvern Madondo, Yuan Shao, Yingzi Liu +3
Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Tr…
Stereotactic Arrhythmia Radioablation for Refractory Ventricular Tachycardia: A Narrative Review and Exploratory Pooled Analysis of Clinical Outcomes and Toxicity
Keyur D. Shah, Chih-Wei Chang, Sibo Tian +6
Purpose: Stereotactic arrhythmia radioablation (STAR) is a non-invasive salvage therapy for refractory ventricular tachycardia (VT), especially in patients ineligible for catheter…
Clinically Interpretable Survival Risk Stratification in Head and Neck Cancer Using Bayesian Networks and Markov Blankets
Keyur D. Shah, Ibrahim Chamseddine, Xiaohan Yuan +8
Purpose: To identify a clinically interpretable subset of survival-relevant features in HN cancer using Bayesian Network (BN) and evaluate its prognostic and causal utility. Method…