10 papers · 1 filter
Circulating Lymphocytes Preservation in Lung Cancer Stereotactic Body Radiation Therapy with Ultra-Fast Proton Delivery Using Modularized Pin Ridge Filters
Duncan Bohannon, Ahmal Jawad Zafar, Sibo Tian +9
Purpose: Radiation-induced lymphopenia is an increasingly recognized toxicity in lung radiotherapy and has been linked to radiation exposure to circulating lymphocytes (CL). In int…
A Digital Twin Framework for Adaptive Treatment Planning in Radiotherapy
Chih-Wei Chang, Sri Sai Akkineni, Mingzhe Hu +7
The development of a digital twin (DT) framework for fast online adaptive proton therapy planning in prostate stereotactic body radiation therapy (SBRT) with dominant intraprostati…
Optimizing Transmission FLASH Radiotherapy for Large-Field Post-Mastectomy Breast Treatment
Ahmal Jawad Zafar, Sunil William Dutta, Matthew Joseph Case +5
We investigated the effects of scanning speed, beam configuration, and dose-rate modeling on the FLASH effect in post-mastectomy proton transmission-beam (TB) planning and evaluate…
Patient-Specific Deep Reinforcement Learning for Automatic Replanning in Head-and-Neck Cancer Proton Therapy
Malvern Madondo, Yuan Shao, Yingzi Liu +3
Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Tr…
Clinically Interpretable Survival Risk Stratification in Head and Neck Cancer Using Bayesian Networks and Markov Blankets
Keyur D. Shah, Ibrahim Chamseddine, Xiaohan Yuan +8
Purpose: To identify a clinically interpretable subset of survival-relevant features in HN cancer using Bayesian Network (BN) and evaluate its prognostic and causal utility. Method…
A Comparative Dosimetric Study of Proton and Photon Therapy in Stereotactic Arrhythmia Radioablation for Ventricular Tachycardia
Keyur D. Shah, Chih-Wei Chang, Pretesh Patel +8
Purpose: VT is a life-threatening arrhythmia commonly treated with catheter ablation; however, some cases remain refractory to conventional treatment. STAR has emerged as a non-inv…