3 papers
stat.ME2026
Rapid evaluation and calibration of Bayesian group sequential designs via conjugate-mixture semi-simulation
Zhangyi He, Feng Yu, Suzie Cro +1
Bayesian group sequential designs (GSDs) extend frequentist GSDs with interpretable decision-making and external evidence borrowing, but their use is limited by the computational b…
stat.ME2026
From aggressive to conservative early stopping in Bayesian group sequential designs
Zhangyi He, Feng Yu, Suzie Cro +1
Group sequential designs (GSDs) are widely used in confirmatory trials to allow interim monitoring while preserving control of the type I error rate. In the frequentist framework,…
stat.ME2025
Optimal scheduling of interim analyses in group sequential trials
Zhangyi He, Suzie Cro, Laurent Billot
Group sequential designs (GSDs) are well established and the most commonly used adaptive design in confirmatory clinical trials with interim analyses. However, they remain underuti…