3 papers
cs.CL2025
From Knowledge to Treatment: Large Language Model Assisted Biomedical Concept Representation for Drug Repurposing
Chengrui Xiang, Tengfei Ma, Xiangzheng Fu +3
Drug repurposing plays a critical role in accelerating treatment discovery, especially for complex and rare diseases. Biomedical knowledge graphs (KGs), which encode rich clinical…
q-bio.QM2024
MoFormer: Multi-objective Antimicrobial Peptide Generation Based on Conditional Transformer Joint Multi-modal Fusion Descriptor
Li Wang, Xiangzheng Fu, Jiahao Yang +5
Deep learning holds a big promise for optimizing existing peptides with more desirable properties, a critical step towards accelerating new drug discovery. Despite the recent emerg…
q-bio.QM2024
HMAMP: Hypervolume-Driven Multi-Objective Antimicrobial Peptides Design
Li Wang, Yiping Li, Xiangzheng Fu +4
Antimicrobial peptides (AMPs) have exhibited unprecedented potential as biomaterials in combating multidrug-resistant bacteria. Despite the increasing adoption of artificial intell…