58 citations · 169 across the 7 of their papers we have counts for
7 papers
Deciphering hierarchical organization of topologically associated domains through change-point testing
Haipeng Xing, Yingru Wu, Yong Chen +1
Background: The nucleus of eukaryotic cells spatially packages chromosomes into a hierarchical and distinct segregation that plays critical roles in maintaining transcription regul…
Single-cell stochastic gene expression kinetics with coupled positive-plus-negative feedback
Chen Jia, Le Yi Wang, George G. Yin +1
Here we investigate single-cell stochastic gene expression kinetics in a minimal coupled gene circuit with positive-plus-negative feedback. A triphasic stochastic bifurcation upon…
Exact power spectrum in a minimal hybrid model of stochastic gene expression oscillations
Chen Jia, Hong Qian, Michael Q. Zhang
Stochastic oscillations in individual cells are usually characterized by a non-monotonic power spectrum with an oscillatory autocorrelation function. Here we develop an analytical…
Relaxation rates of gene expression kinetics reveal the feedback signs of autoregulatory gene networks
Chen Jia, Hong Qian, Min Chen +1
The transient response to a stimulus and subsequent recovery to a steady state are the fundamental characteristics of a living organism. Here we study the relaxation kinetics of au…
Emergent Lévy behavior in single-cell stochastic gene expression
Chen Jia, Michael Q. Zhang, Hong Qian
Single-cell gene expression is inherently stochastic; its emergent behavior can be defined in terms of the chemical master equation describing the evolution of the mRNA and protein…
Stochastic fluctuations can reveal the feedback signs of gene regulatory networks at the single-molecule level
Chen Jia, Peng Xie, Min Chen +1
Understanding the relationship between spontaneous stochastic fluctuations and the topology of the underlying gene regulatory network is of fundamental importance for the study of…