2 papers
stat.ME2025
Optimal and Efficient Sample Size Re-estimation: A Dynamic Cost Framework
Rui Jin, Cai Wu, Qiqi Deng
Adaptive sample size re-estimation (SSR) is a well-established strategy for improving the efficiency and flexibility of clinical trials. Its central challenge is determining whethe…
stat.AP2024
The Modified Combo i3+3 Design for Novel-Novel Combination Dose-Finding Trials in Oncology
Jiaxin Liu, Shijie Yuan, Qiqi Deng +1
We consider a modified Ci3+3 (MCi3+3) design for dual-agent dose-finding trials in which both agents are tested on multiple doses. This usually happens when the agents are novel th…