2 papers
stat.ME2025
Optimal and Efficient Sample Size Re-estimation: A Dynamic Cost Framework
Rui Jin, Cai Wu, Qiqi Deng
Adaptive sample size re-estimation (SSR) is a well-established strategy for improving the efficiency and flexibility of clinical trials. Its central challenge is determining whethe…
stat.ME2025
Futility Analysis under Scrutiny
Rui Jin, Cai Wu, Peter Mesenbrink
This paper investigates the robustness of futility analyses in clinical trials when interim analysis population deviates from the target population. We demonstrate how population s…