5 papers
Neural Diffusion Processes for Physically Interpretable Survival Prediction
Alessio Cristofoletto, Cesare Rollo, Giovanni Birolo +1
We introduce DeepFHT, a survival-analysis framework that couples deep neural networks with first hitting time (FHT) distributions from stochastic process theory. Time to event is r…
Beyond Cox Models: Assessing the Performance of Machine-Learning Methods in Non-Proportional Hazards and Non-Linear Survival Analysis
Ivan Rossi, Flavio Sartori, Cesare Rollo +3
Survival analysis often relies on Cox models, assuming both linearity and proportional hazards (PH). This study evaluates machine and deep learning methods that relax these constra…
Sparsity is All You Need: Rethinking Biological Pathway-Informed Approaches in Deep Learning
Isabella Caranzano, Corrado Pancotti, Cesare Rollo +4
Biologically-informed neural networks typically leverage pathway annotations to enhance performance in biomedical applications. We hypothesized that the benefits of pathway integra…
JanusDDG: A Thermodynamics-Compliant Model for Sequence-Based Protein Stability via Two-Fronts Multi-Head Attention
Guido Barducci, Ivan Rossi, Francesco Codicè +6
Understanding how residue variations affect protein stability is crucial for designing functional proteins and deciphering the molecular mechanisms underlying disease-related mutat…
SurvHive: a package to consistently access multiple survival-analysis packages
Giovanni Birolo, Ivan Rossi, Flavio Sartori +3
Survival analysis, a foundational tool for modeling time-to-event data, has seen growing integration with machine learning (ML) approaches to handle the complexities of censored da…