5 papers
Reshaping Biomolecular Structure Prediction through Strategic Conformational Exploration with HelixFold-S1
Lihang Liu, Yang Liu, Xianbin Ye +6
Generating large ensembles of candidate conformations is standard for improving biomolecular structure prediction. Yet aimless sampling is inefficient and costly, producing many re…
HelixDesign-Antibody: A Scalable Production-Grade Platform for Antibody Design Built on HelixFold3
Jie Gao, Jing Hu, Shanzhuo Zhang +5
Antibody engineering is essential for developing therapeutics and advancing biomedical research. Traditional discovery methods often rely on time-consuming and resource-intensive e…
HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3
Jie Gao, Jun Li, Jing Hu +5
Protein binder design is central to therapeutics, diagnostics, and synthetic biology, yet practical deployment remains challenging due to fragmented workflows, high computational c…
Technical Report of HelixFold3 for Biomolecular Structure Prediction
Lihang Liu, Shanzhuo Zhang, Yang Xue +10
The AlphaFold series has transformed protein structure prediction with remarkable accuracy, often matching experimental methods. AlphaFold2, AlphaFold-Multimer, and the latest Alph…
Precise Antigen-Antibody Structure Predictions Enhance Antibody Development with HelixFold-Multimer
Jie Gao, Jing Hu, Lihang Liu +4
The accurate prediction of antigen-antibody structures is essential for advancing immunology and therapeutic development, as it helps elucidate molecular interactions that underlie…