3 papers
q-bio.BM2025
Reshaping Biomolecular Structure Prediction through Strategic Conformational Exploration with HelixFold-S1
Lihang Liu, Yang Liu, Xianbin Ye +6
Generating large ensembles of candidate conformations is standard for improving biomolecular structure prediction. Yet aimless sampling is inefficient and costly, producing many re…
q-bio.BM2024
Technical Report of HelixFold3 for Biomolecular Structure Prediction
Lihang Liu, Shanzhuo Zhang, Yang Xue +10
The AlphaFold series has transformed protein structure prediction with remarkable accuracy, often matching experimental methods. AlphaFold2, AlphaFold-Multimer, and the latest Alph…
q-bio.BM2024
Joint Design of 5' Untranslated Region and Coding Sequence of mRNA
Yang Liu, Jie Gao, Xiaonan Zhang +1
Messenger RNA (mRNA) vaccines and therapeutics are emerging as powerful tools against a variety of diseases, including infectious diseases and cancer. The design of mRNA molecules,…