40 citations · 57 across the 6 of their papers we have counts for
6 papers · 1 filter
Comparing restricted mean survival times in small sample clinical trials using pseudo-observations
David Jesse, Cynthia Huber, Tim Friede
The widely used proportional hazard assumption cannot be assessed reliably in small-scale clinical trials and might often in fact be unjustified, e.g. due to delayed treatment effe…
A two-step approach for analyzing time to event data under non-proportional hazards
Jonas Brugger, Tim Friede, Florian Klinglmüller +3
The log-rank test and the Cox proportional hazards model are commonly used to compare time-to-event data in clinical trials, as they are most powerful under proportional hazards. B…
Subgroup identification using individual participant data from multiple trials on low back pain
Cynthia Huber, Tim Friede
Model-based recursive partitioning (MOB) and its extension, metaMOB, are potent tools for identifying subgroups with differential treatment effects. In the metaMOB approach random…
A neutral comparison of statistical methods for time-to-event analyses under non-proportional hazards
Florian Klinglmüller, Tobias Fellinger, Franz König +10
While well-established methods for time-to-event data are available when the proportional hazards assumption holds, there is no consensus on the best inferential approach under non…
The impact of neglected confounding and interactions in mixed-effects meta-regression
Eric S. Knop, Markus Pauly, Tim Friede +1
Analysts seldom include interaction terms in meta-regression model, what can introduce bias if an interaction is present. We illustrate this in the current paper by re-analyzing an…
On the role of benchmarking data sets and simulations in method comparison studies
Sarah Friedrich, Tim Friede
Method comparisons are essential to provide recommendations and guidance for applied researchers, who often have to choose from a plethora of available approaches. While many compa…