6 papers
Active flows drive anchoring of nematics at rigid walls
Michael Fang, Ioannis Hadjifrangiskou, Sumesh P. Thampi +2
Although confinement strongly influences flows in active materials, it remains unclear how active particles align at rigid boundaries when no thermodynamic anchoring is imposed. We…
Why Extensile and Contractile Tissues Could be Hard to Tell Apart
Jan Rozman, Sumesh P. Thampi, Julia M. Yeomans
Active nematic models explain the topological defects and flow patterns observed in epithelial tissues, but the nature of active stress-whether it is extensile or contractile, a ke…
Junctional-Fluctuation-Mediated Fluidisation of Multi-Phase Field Epithelial Monolayers
James N. Graham, Jan Rozman
We analyse a multi-phase field model for an epithelial monolayer with pairwise adhesions between neighbouring cells following an Ornstein-Uhlenbeck process, representing the stocha…
Spontaneous Hole Formation in Cell Monolayers Emerges from Collective Cell Motion
Diogo E. P. Pinto, Jan Rozman, Julia M. Yeomans
Although cell monolayers typically remain confluent, they can spontaneously develop persistent holes as a result of collective cellular motion. Recent studies on MDCK monolayers cu…
Cell-level modelling of homeostasis in confined epithelial monolayers
KVS Chaithanya, Jan Rozman, Andrej Košmrlj +1
Tissue homeostasis, the biological process of maintaining a steady state in tissue via control of cell proliferation, death, and metabolic function, is essential for the developmen…
Vertex model with internal dissipation enables sustained flows
Jan Rozman, Chaithanya K. V. S., Julia M. Yeomans +1
Complex tissue flows in epithelia are driven by intra- and inter-cellular processes that generate, maintain, and coordinate mechanical forces. There has been growing evidence that…