5 papers
CAP: Commutative Algebra Prediction of Protein-Nucleic Acid Binding Affinities
Mushal Zia, Faisal Suwayyid, Yuta Hozumi +3
An accurate prediction of protein-nucleic acid binding affinity is vital for deciphering genomic processes, yet existing approaches often struggle in reconciling high accuracy with…
Commutative algebra neural network reveals genetic origins of diseases
JunJie Wee, Faisal Suwayyid, Mushal Zia +3
Genetic mutations can disrupt protein structure, stability, and solubility, contributing to a wide range of diseases. Existing predictive models often lack interpretability and fai…
CAKR: Commutative algebra k-mer representations for genomics
Faisal Suwayyid, Yuta Hozumi, Hongsong Feng +3
Despite the availability of various sequence analysis models, comparative genomic analysis remains a challenge in genomics, genetics, and phylogenetics. Commutative algebra, a fund…
CAML: Commutative algebra machine learning -- a case study on protein-ligand binding affinity prediction
Hongsong Feng, Faisal Suwayyid, Mushal Zia +4
Recently, Suwayyid and Wei have introduced commutative algebra as an emerging paradigm for machine learning and data science. In this work, we integrate commutative algebra machine…
Revealing the Shape of Genome Space via K-mer Topology
Yuta Hozumi, Guo-Wei Wei
Despite decades of effort, understanding the shape of genome space in biology remains a challenge due to the similarity, variability, diversity, and plasticity of evolutionary rela…