2 papers
physics.med-ph2025
Verification, Validation, and Uncertainty Quantification (VVUQ) of Physiologically Based Pharmacokinetic Models for Theranostic Digital Twins: Towards Reliable Model-Informed Treatment Planning for Radiopharmaceutical Therapies
Nouran R. R. Zaid, Deni Hardiansyah, Tahir Yusufaly +1
Physiologically based pharmacokinetic (PBPK) models provide a mechanistic framework for simulating radiopharmaceutical kinetics and estimating patient-specific absorbed doses (ADs)…
physics.med-ph2025
An Overview of Physiologically Based Pharmacokinetic (PBPK) and Population Pharmacokinetic (PopPK) Models
Deni Hardiansyah, Bisma Baron Patrianesha, Kuangyu Shi +3
This review discusses the current applications, advantages, and limitations of PBPK and PopPK models in radiopharmaceutical therapy (RPT). PBPK models simulate radiopharmaceutical…