2.5k citations · 2.5k across the 7 of their papers we have counts for
7 papers
High-throughput validation of ceRNA regulatory networks
Hua-Sheng Chiu, María Rodríguez Martínez, Mukesh Bansal +5
Background: MicroRNAs (miRNAs) play multiple roles in tumor biology [1]. Interestingly, reports from multiple groups suggest that miRNA targets may be coupled through competitive s…
Searching for Gene Sets with Mutually Exclusive Mutations
Paul Ginzberg, Federico Giorgi, Andrea Califano
Cancer cells evolve through random somatic mutations. "Beneficial" mutations which disrupt key pathways (e.g. cell cycle regulation) are subject to natural selection. Multiple muta…
Multivariate dependence and genetic networks inference
Adam A. Margolin, Kai Wang, Andrea Califano +1
A critical task in systems biology is the identification of genes that interact to control cellular processes by transcriptional activation of a set of target genes. Many methods h…
A Pattern Discovery-Based Method for Detecting Multi-Locus Genetic Association
Zhong Li, Aris Floratos, David Wang +1
Methods to effectively detect multi-locus genetic association are becoming increasingly relevant in the genetic dissection of complex trait in humans. Current approaches typically…
Conditional Network Analysis Identifies Candidate Regulator Genes in Human B Cells
Kai Wang, Nilanjana Banerjee, Adam Margolin +4
Cellular phenotypes are determined by the dynamical activity of networks of co-regulated genes. Elucidating such networks is crucial for the understanding of normal cell physiology…
ARACNE: An Algorithm for the Reconstruction of Gene Regulatory Networks in a Mammalian Cellular Context
Adam A. Margolin, Ilya Nemenman, Katia Basso +5
Background: Elucidating gene regulatory networks is crucial for understanding normal cell physiology and complex pathologic phenotypes. Existing computational methods for the genom…