2 papers
stat.ME2025
ETZ: A Modeling Principle for Confirmability of Drug-Development Studies
Yujia Sun, Yang Han, Xingya Wang +3
Transitioning from Phase 2 to Phase 3 in drug development, at a rate of 40%, is the most stringent among phase transitions (Hay et al. (2014)). Yet, success rate at Phase…
stat.ML2025
Counterfactual Uncertainty Quantification of Factual Estimand of Efficacy from Before-and-After Treatment Repeated Measures Randomized Controlled Trials
Xingya Wang, Yang Han, Yushi Liu +2
This article quantifies the uncertainty reduction achievable for \textit{counterfactual} estimand, and cautions against potential bias when the estimand uses Digital Twins. Posed b…