3 papers
physics.chem-ph2025
Kinetics of seeded protein aggregation: theory and application
Alexander J. Dear, Georg Meisl, Jing Hu +2
``Seeding'' is the addition of preformed fibrils to a solution of monomeric protein to accelerate its aggregation into new fibrils. It is a versatile and widely-used tool for scien…
physics.chem-ph2025
General integrated rate law for complex self-assembly reactions reveals the mechanism of amyloid-beta co-aggregation
Alexander J. Dear, Georg Meisl, Emil Axell +5
Analyzing kinetic experiments on protein aggregation using integrated rate laws has led to numerous advances in our understanding of the fundamental chemical mechanisms behind amyl…
cond-mat.soft2024
Competing addition processes give distinct growth regimes in the assembly of 1D filaments
Sk Ashif Akram, Tyler Brown, Stephen Whitelam +3
We present a model to describe the concentration-dependent growth of protein filaments. Our model contains two states, a low entropy/high affinity ordered state and a high entropy/…