2 papers
q-bio.BM2004
Hybridization Isotherms of DNA Microarrays and the Quantification of Mutation Studies
Avraham Halperin, Arnaud Buhot, Ekaterina B. Zhulina
Background: Diagnostic DNA arrays for detection of point mutations as markers for cancer usually function in the presence of a large excess of wild type DNA. This excess can give r…
cond-mat.soft2003
Sensitivity, Specificity and the Hybridization Isotherms of DNA Chips
A. Halperin, A. Buhot, E. B. Zhulina
Competitve hybridization, at the surface and in the bulk, lowers the sensitivity of DNA chips. Competitive surface hybridization occurs when different targets can hybridize with th…