2 papers
q-bio.BM2004
Prediction of site-specific amino acid distributions and limits of divergent evolutionary changes in protein sequences
Markus Porto, H. Eduardo Roman, Michele Vendruscolo +1
We derive an analytic expression for site-specific stationary distributions of amino acids from the Structurally Constrained Neutral (SCN) model of protein evolution with conservat…
cond-mat.stat-mech1998
Neutral evolution of model proteins: diffusion in sequence space and overdispersion
Ugo Bastolla, H. Eduardo Roman, Michele Vendruscolo
We simulate the evolution of model protein sequences subject to mutations. A mutation is considered neutral if it conserves 1) the structure of the ground state, 2) its thermodynam…