3 papers
physics.bio-ph2025
Twin Supercoil Domain couples the dynamics of molecular motors and plectonemes during bacterial DNA transcription and replication
Marc Joyeux
The genomic DNA of most bacteria is significantly underwound, which constrains the DNA molecule to adopt a branched plectoneme geometry. Moreover, biological functions like replica…
physics.bio-ph2024
Transcribing RNA polymerases: Dynamics of Twin Supercoiled Domains
Marc Joyeux
Gene transcription by a RNA Polymerase (RNAP) enzyme requires that double-stranded DNA be locally and transiently opened, which results in an increase of DNA supercoiling downstrea…
physics.bio-ph2024
Tethered Particle Motion Technique in Crowded Media: Compaction of DNA by Globular Macromolecules
Marc Joyeux
Tethered Particle Motion (TPM) is a single molecule technique, which consists in tracking the motion of a nano-particle (NP) immersed in a fluid and tethered to a glass surface by…