3 papers
q-bio.GN2025
Context-Aware Regularization with Markovian Integration for Attention-Based Nucleotide Analysis
Mohammadsaleh Refahi, Mahdi Abavisani, Bahrad A. Sokhansanj +2
Transformers have revolutionized nucleotide sequence analysis, yet capturing long-range dependencies remains challenging. Recent studies show that autoregressive transformers often…
cs.LG2025
Learning to Align Molecules and Proteins: A Geometry-Aware Approach to Binding Affinity
Mohammadsaleh Refahi, Bahrad A. Sokhansanj, James R. Brown +1
Accurate prediction of drug-target binding affinity can accelerate drug discovery by prioritizing promising compounds before costly wet-lab screening. While deep learning has advan…
q-bio.GN2025
Fast and Scalable Gene Embedding Search: A Comparative Study of FAISS and ScaNN
Mohammad Saleh Refahi, Gavin Hearne, Harrison Muller +4
The exponential growth of DNA sequencing data has outpaced traditional heuristic-based methods, which struggle to scale effectively. Efficient computational approaches are urgently…