3 papers
math.DS2026
Ghost Dynamics in Receptor Signalling Networks: A Fast--Slow Adaptive Extension of Competitive Cancer Inhibition Models
G Manjunath, Roumen Anguelov
Receptor occupancy models quantify inhibition of cancer signalling, often treating target occupancy as a proxy for downstream activity. Although this simplification yields low-dime…
q-bio.QM2026
Quantifying antiproliferative effects of quinolinic acid on melanoma, macrophage and keratinocyte cells using a parametric cell-viability model
Roumen Anguelov, Charlise Basson, Yvette N. Hlophe +4
This paper presents a robust mathematical framework for quantifying antiproliferative effects from noisy in vitro cell viability experiments. The methodology is demonstrated using…
q-bio.MN2025
A Mathematical Model of the Cell Cycle: Exploring the Impact of Zingerone on Cancer Cell Proliferation
Roumen Anguelov, Micaela Goddard, Yvette Hlophe +2
This paper presents a mathematical model that explores the interactions between Cyclin-Dependent Kinase 1 (CDK1) and the Anaphase-Promoting Complex (APC) in cancer cells. Through t…