5 papers
Theoretical Guarantees for Causal Discovery on Large Random Graphs
Mathieu Chevalley, Arash Mehrjou, Patrick Schwab
We investigate theoretical guarantees for the false-negative rate (FNR) -- the fraction of true causal edges whose orientation is not recovered, under single-variable random interv…
Deriving Causal Order from Single-Variable Interventions: Guarantees & Algorithm
Mathieu Chevalley, Patrick Schwab, Arash Mehrjou
Targeted and uniform interventions to a system are crucial for unveiling causal relationships. While several methods have been developed to leverage interventional data for causal…
In-silico biological discovery with large perturbation models
Djordje Miladinovic, Tobias Höppe, Mathieu Chevalley +6
Data generated in perturbation experiments link perturbations to the changes they elicit and therefore contain information relevant to numerous biological discovery tasks -- from u…
Multi-megabase scale genome interpretation with genetic language models
Frederik Träuble, Lachlan Stuart, Andreas Georgiou +9
Understanding how molecular changes caused by genetic variation drive disease risk is crucial for deciphering disease mechanisms. However, interpreting genome sequences is challeng…
Efficient Differentiable Discovery of Causal Order
Mathieu Chevalley, Arash Mehrjou, Patrick Schwab
In the algorithm Intersort, Chevalley et al. (2024) proposed a score-based method to discover the causal order of variables in a Directed Acyclic Graph (DAG) model, leveraging inte…