3 papers
q-bio.QM2025
tcrLM: a lightweight protein language model for predicting T cell receptor and epitope binding specificity
Xing Fang, Chenpeng Yu, Shiye Tian +1
The anti-cancer immune response relies on the bindings between T-cell receptors (TCRs) and antigens, which elicits adaptive immunity to eliminate tumor cells. This ability of the i…
q-bio.BM2025
Phenotypic Profile-Informed Generation of Drug-Like Molecules via Dual-Channel Variational Autoencoders
Hui Liu, Shiye Tian, Xuejun Liu
The de novo generation of drug-like molecules capable of inducing desirable phenotypic changes is receiving increasing attention. However, previous methods predominantly rely on ex…
q-bio.BM2025
A unified cross-attention model for predicting antigen binding specificity to both HLA and TCR molecules
Chenpeng Yu, Xing Fang, Hui Liu
The immune checkpoint inhibitors have demonstrated promising clinical efficacy across various tumor types, yet the percentage of patients who benefit from them remains low. The bin…