2 papers
q-bio.QM2025
tcrLM: a lightweight protein language model for predicting T cell receptor and epitope binding specificity
Xing Fang, Chenpeng Yu, Shiye Tian +1
The anti-cancer immune response relies on the bindings between T-cell receptors (TCRs) and antigens, which elicits adaptive immunity to eliminate tumor cells. This ability of the i…
q-bio.BM2025
A unified cross-attention model for predicting antigen binding specificity to both HLA and TCR molecules
Chenpeng Yu, Xing Fang, Hui Liu
The immune checkpoint inhibitors have demonstrated promising clinical efficacy across various tumor types, yet the percentage of patients who benefit from them remains low. The bin…