3 papers
stat.ME2021
Parameter estimation in nonlinear mixed effect models based on ordinary differential equations: an optimal control approach
Quentin Clairon, Chloé Pasin, Irene Balelli +2
We present a parameter estimation method for nonlinear mixed effect models based on ordinary differential equations (NLME-ODEs). The method presented here aims at regularizing the…
stat.ME2019
Effects of interventions and optimal strategies in the stochastic system approach to causality
Daniel Commenges, Mélanie Prague
We consider the problem of defining the effect of an intervention on a time-varying risk factor or treatment for a disease or a physiological marker; we develop here the latter cas…
stat.AP2016
Modeling CD4+ T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7
Ana Jarne, Daniel Commenges, Mélanie Prague +2
Combination Antiretroviral Therapy (cART) succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4 T cells…