2 citations · 3 across the 6 of their papers we have counts for
7 papers
Neural ODE enhanced linear mixed effect models for estimating complex association patterns of time-varying covariates with the marker trajectory
Zhe Aurore Li, Quentin Clairon, Cécilia Samieri +3
Longitudinal cohort studies produce repeated data that enable the assessment of time-varying association patterns between exposures and health outcomes. Classical linear mixed-effe…
Variational autoencoder for inference of nonlinear mixed effect models based on ordinary differential equations
Zhe Li, Mélanie Prague, Rodolphe Thiébaut +1
We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudin…
Parameter estimation in nonlinear mixed effect models based on ordinary differential equations: an optimal control approach
Quentin Clairon, Chloé Pasin, Irene Balelli +2
We present a parameter estimation method for nonlinear mixed effect models based on ordinary differential equations (NLME-ODEs). The method presented here aims at regularizing the…
Robust and Efficient Optimization Using a Marquardt-Levenberg Algorithm with R Package marqLevAlg
Viviane Philipps, Boris P Hejblum, Mélanie Prague +2
Implementations in R of classical general-purpose algorithms for local optimization generally have two major limitations which cause difficulties in applications to complex problem…
Effects of interventions and optimal strategies in the stochastic system approach to causality
Daniel Commenges, Mélanie Prague
We consider the problem of defining the effect of an intervention on a time-varying risk factor or treatment for a disease or a physiological marker; we develop here the latter cas…
Modeling CD4+ T cells dynamics in HIV-infected patients receiving repeated cycles of exogenous Interleukin 7
Ana Jarne, Daniel Commenges, Mélanie Prague +2
Combination Antiretroviral Therapy (cART) succeeds to control viral replication in most HIV infected patients. This is normally followed by a reconstitution of the CD4 T cells…
Dynamic models for estimating the effect of HAART on CD4 in observational studies: application to the Aquitaine Cohort study and the Swiss HIV Cohort Study
M. Prague, D. Commenges, J. M. Gran +4
Highly active antiretroviral therapy (HAART) has proved efficient in increasing CD4 counts in many randomized clinical trials. Because randomized trials have some limitations (e.g.…