50 citations · 66 across the 6 of their papers we have counts for
Showing 2018Show all
3 papers · 1 filter
stat.AP2018★ 50 cited
Recent advances in methodology for clinical trials in small populations: the InSPiRe project
T. Friede, M. Posch, S. Zohar +19
Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This l…
stat.AP2018
Optimal Design in Hierarchical Models with application in Multi-center Trials
Maryna Prus, Norbert Benda, Rainer Schwabe
Hierarchical random effect models are used for different purposes in clinical research and other areas. In general, the main focus is on population parameters related to the expect…
stat.OT2018
On estimands and the analysis of adverse events in the presence of varying follow-up times within the benefit assessment of therapies
Steffen Unkel, Marjan Amiri, Norbert Benda +14
The analysis of adverse events (AEs) is a key component in the assessment of a drug's safety profile. Inappropriate analysis methods may result in misleading conclusions about a th…