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stat.AP2019
Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials
Tobias Mütze, Susanna Salem, Norbert Benda +2
Blinded sample size re-estimation and information monitoring based on blinded data has been suggested to mitigate risks due to planning uncertainties regarding nuisance parameters.…
stat.AP2018
Recent advances in methodology for clinical trials in small populations: the InSPiRe project
T. Friede, M. Posch, S. Zohar +19
Where there are a limited number of patients, such as in a rare disease, clinical trials in these small populations present several challenges, including statistical issues. This l…
stat.AP2018
Optimal Design in Hierarchical Models with application in Multi-center Trials
Maryna Prus, Norbert Benda, Rainer Schwabe
Hierarchical random effect models are used for different purposes in clinical research and other areas. In general, the main focus is on population parameters related to the expect…