4 papers
Non-Identifiable Pedigrees and a Bayesian Solution
B. Kirkpatrick
Some methods aim to correct or test for relationships or to reconstruct the pedigree, or family tree. We show that these methods cannot resolve ties for correct relationships due t…
Correcting for Cryptic Relatedness in Genome-Wide Association Studies
Bonnie Kirkpatrick, Alexandre Bouchard-Côté
While the individuals chosen for a genome-wide association study (GWAS) may not be closely related to each other, there can be distant (cryptic) relationships that confound the evi…
Fast Computation of the Kinship Coefficients
Bonnie Kirkpatrick
For families, kinship coefficients are quantifications of the amount of genetic sharing between a pair of individuals. These coefficients are critical for understanding the breedin…
Haplotype Inference for Pedigrees with Few Recombinations
Bonnie Kirkpatrick
Pedigrees, or family trees, are graphs of family relationships that are used to study inheritance. A fundamental problem in computational biology is to find, for a pedigree with $n…