80 citations · 256 across the 11 of their papers we have counts for
5 papers · 1 filter
The role of antigen-competitive dynamics in regulating the immune response
Pantea Pooladvand, Peter S. Kim, Barbara Fazekas de St Groth
The clonal expansion of T cells during an infection is tightly regulated to ensure an appropriate immune response against invading pathogens. Although experiments have mapped the t…
The role of viral infectivity in oncolytic virotherapy outcomes: A mathematical study
Pantea Pooladvand, Chae-Ok Yun, A-Rum Yoon +2
A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by unin…
Mathematical model for delayed responses in immune checkpoint blockades
Collin Y. Zheng, Peter S. Kim
We introduce a set of ordinary differential equations (ODE) that qualitatively reproduces delayed responses observed in immune checkpoint blockade therapy (e.g. anti-CTLA-4 Ipilimu…
Oncolytic virotherapy for tumours following a Gompertz growth law
Adrianne L. Jenner, Peter S. Kim, Federico Frascoli
We present a mathematical model describing oncolytic virotherapy treatment of a tumour that proliferates according to a Gompertz growth function. We present local stability analysi…
Effects of mutations and immunogenicity on outcomes of anti-cancer therapies for secondary lesions
Elena Piretto, Marcello Delitala, Peter S. Kim +1
Cancer development is driven by mutations and selective forces, including the action of the immune system and interspecific competition. When administered to patients, anti-cancer…