6 papers
Growth and site-specific organization of micron-scale biomolecular devices on living mammalian cells
Sisi Jia, Siew Cheng Phua, Yuta Nihongaki +7
Mesoscale molecular assemblies on the cell surface, such as cilia and filopodia, integrate information, control transport and amplify signals. Synthetic devices mimicking these str…
On the Transcriptomic Signature and General Stress State Associated with Aneuploidy
Hung-Ji Tsai, Anjali R. Nelliat, Andrei Kucharavy +4
Whether aneuploid cells with diverse karyotypes have any properties in common has a been a subject of intense interest. A recent study by Terhorst et al. (1) reinvestigated the com…
Biophysics at the coffee shop: lessons learned working with George Oster
Oleg Igoshin, Jing Chen, Jianhua Xing +9
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerst…
Building the Space Elevator: Lessons from Biological Design
Dan M. Popescu, Sean X. Sun
One of the biggest perceived challenges in building megastructures, such as the space elevator, is the unavailability of materials with sufficient tensile strength. The presumed ne…
Inertia and Prediction in the Response to External Perturbation of Noisy Variables
Nash Rochman, Sean X. Sun
For most stochastic dynamical systems, variables which are tightly regulated tend to respond slowly to external changes. This idea is often discussed for applicable systems, within…
To Grow is Not Enough: Impact of Noise on Cell Environmental Response and Fitness
Nash Rochman, Fangwei Si, Sean X. Sun
Quantitative single cell measurements have shown that cell cycle duration (the time between cell divisions) for diverse cell types is a noisy variable. The underlying distribution…