6 papers
Activity-dependent epidemic spreading on multiscale brain networks predicts Alzheimer's disease progression
Christoffer G. Alexandersen, Suman S. Kulkarni, Jessica T. Davis +3
Neurodegenerative diseases can be viewed as spreading processes on brain networks, in which pathological proteins propagate between anatomically connected brain regions. Mathematic…
Quantifying the cost of network computations to unpack structure-function relationships in the brain
Suman S. Kulkarni, Jason Z. Kim, Panagiotis Fotiadis +2
The brain supports computations through coordinated patterns of activity on an underlying network. These networks---from microscale navigational circuits in insects to macroscale b…
QUIET: Quantifying Underutilized Influential Edges for Targeted Synchronization
Sovesh Mohapatra, Christoffer G. Alexandersen, Panagiotis Fotiadis +4
Network control theory can be used to model intrinsic and extrinsic strategies to steer neural dynamics. Standard approaches are node-centric, structural, and focused on achieving…
Linear control theory for jammed particle systems
Erin G. Teich, Jason Z. Kim, Dani S. Bassett
Amorphous particulate matter constitutes a wide range of natural and synthetic materials. Despite this ubiquity, the way in which these systems' disordered microstructure couples t…
Habit learning is associated with efficiently controlled network dynamics in naive macaque monkeys
Julia K. Brynildsen, Panagiotis Fotiadis, Karol P. Szymula +5
Primates utilize distributed neural circuits to learn habits in uncertain environments, but the underlying mechanisms remain poorly understood. We propose a formal theory of networ…
Network Models of Neurodegeneration: Bridging Neuronal Dynamics and Disease Progression
Christoffer G. Alexandersen, Georgia S. Brennan, Julia K. Brynildsen +3
Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our underst…