4 papers
Activity-dependent epidemic spreading on multiscale brain networks predicts Alzheimer's disease progression
Christoffer G. Alexandersen, Suman S. Kulkarni, Jessica T. Davis +3
Neurodegenerative diseases can be viewed as spreading processes on brain networks, in which pathological proteins propagate between anatomically connected brain regions. Mathematic…
QUIET: Quantifying Underutilized Influential Edges for Targeted Synchronization
Sovesh Mohapatra, Christoffer G. Alexandersen, Panagiotis Fotiadis +4
Network control theory can be used to model intrinsic and extrinsic strategies to steer neural dynamics. Standard approaches are node-centric, structural, and focused on achieving…
Network Models of Neurodegeneration: Bridging Neuronal Dynamics and Disease Progression
Christoffer G. Alexandersen, Georgia S. Brennan, Julia K. Brynildsen +3
Neurodegenerative diseases are characterized by the accumulation of misfolded proteins and widespread disruptions in brain function. Computational modeling has advanced our underst…
HeMiTo-dynamics: a characterisation of mammalian prion toxicity using non-dimensionalisation, linear stability and perturbation analyses
Johannes G. Borgqvist, Christoffer Gretarsson Alexandersen
Prion-like proteins play crucial parts in biological processes in organisms ranging from yeast to humans. For instance, many neurodegenerative diseases are believed to be caused by…