256 citations · 571 across the 29 of their papers we have counts for
35 papers
Modeling and simulation of electrodiffusion in dense reconstructions of cerebral tissue
Halvor Herlyng, Marius Causemann, Gaute T. Einevoll +3
Excitable tissue is fundamental to brain function, yet its study is complicated by extreme morphological complexity and the physiological processes governing its dynamics. Conseque…
Spatial modeling algorithms for reactions and transport (SMART) in biological cells
Emmet A. Francis, Justin G. Laughlin, Jørgen S. Dokken +4
Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mat…
Scalable approximation and solvers for ionic electrodiffusion in cellular geometries
Pietro Benedusi, Ada J. Ellingsrud, Halvor Herlyng +1
The activity and dynamics of excitable cells are fundamentally regulated and moderated by extracellular and intracellular ion concentrations and their electric potentials. The incr…
Directional flow in perivascular networks: Mixed finite elements for reduced-dimensional models on graphs
Ingeborg G. Gjerde, Miroslav Kuchta, Marie E. Rognes +1
The flow of cerebrospinal fluid through the perivascular spaces of the brain is believed to play a crucial role in eliminating toxic waste proteins. While the driving forces of thi…
The directional flow generated by peristalsis in perivascular networks -- theoretical and numerical reduced-order descriptions
Ingeborg G. Gjerde, Marie E. Rognes, Antonio L. Sanchez
Directional fluid flow in perivascular spaces surrounding cerebral arteries is hypothesized to play a key role in brain solute transport and clearance. While various drivers for pu…
Modeling excitable cells with the EMI equations: spectral analysis and iterative solution strategy
Pietro Benedusi, Paola Ferrari, Marie Rognes +1
In this work, we are interested in solving large linear systems stemming from the Extra-Membrane-Intra (EMI) model, which is employed for simulating excitable tissues at a cellular…