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stat.ME2018
Estimating the treatment effect in a subgroup defined by an early post-baseline biomarker measurement in randomized clinical trials with time-to-event endpoint
Björn Bornkamp, Georgina Bermann
Biomarker measurements can be relatively easy and quick to obtain and they are useful to investigate whether a compound works as intended on a mechanistic, pharmacological level. I…
stat.ME2017
Bayesian optimal designs for dose-response curves with common parameters
Kirsten Schorning, Maria Konstantinou
The issue of determining not only an adequate dose but also a dosing frequency of a drug arises frequently in Phase II clinical trials. This results in the comparison of models whi…