500 citations · 559 across the 13 of their papers we have counts for
3 papers · 1 filter
Standard and reference-based conditional mean imputation
Marcel Wolbers, Alessandro Noci, Paul Delmar +3
Clinical trials with longitudinal outcomes typically include missing data due to missed assessments or structural missingness of outcomes after intercurrent events handled with a h…
Hypothetical estimands in clinical trials: a unification of causal inference and missing data methods
Camila Olarte Parra, Rhian M. Daniel, Jonathan W. Bartlett
The ICH E9 addendum introduces the term intercurrent event to refer to events that happen after randomisation and that can either preclude observation of the outcome of interest or…
Reference based multiple imputation -- what is the right variance and how to estimate it
Jonathan W. Bartlett
Reference based multiple imputation methods have become popular for handling missing data in randomised clinical trials. Rubin's variance estimator is well known to be biased compa…