32 citations · 129 across the 28 of their papers we have counts for
29 papers
Broken Symmetries, Information and Emergence: What is theory, that biology should be mindful of it?
Shakti N. Menon, Sitabhra Sinha
The discipline of `theoretical biology' has been developing from its inception several decades ago almost in parallel with the advances in biology, so much so that the latter is of…
A hierarchy index for networks in the brain reveals a complex entangled organizational structure
Anand Pathak, Shakti N. Menon, Sitabhra Sinha
Networks involved in information processing often have their nodes arranged hierarchically, with the majority of connections occurring in adjacent levels. However, despite being an…
Lateral inhibition in relaxation oscillators provides a basis for computation
A. Parveena Shamim, Shakti N. Menon, Sitabhra Sinha
Coupled relaxation oscillators, realized via chemical or other means, can exhibit a multiplicity of steady states, characterized by spatial patterns resulting from lateral inhibiti…
Phototactic cyanobacteria as an active matter system
P. Varuni, Shakti N. Menon, Gautam I. Menon
Flocks of birds, schools of fish, mixtures of motors and cytoskeletal filaments, swimming bacteria and driven granular media are systems of interacting motile units that exhibit co…
Flags, Landscapes and Signaling: Contact-mediated inter-cellular interactions enable plasticity in fate determination driven by positional information
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
Multicellular organisms exhibit a high degree of structural organization with specific cell types always occurring in characteristic locations. The conventional framework for descr…
Contact-mediated signaling enables disorder-driven transitions in cellular assemblies
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
We show that when cells communicate by contact-mediated interactions, heterogeneity in cell shapes and sizes leads to qualitatively distinct collective behavior in the tissue. For…
Precision of morphogen-driven tissue patterning during development is enhanced through contact-mediated cellular interactions
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
Embryonic development involves pattern formation characterized by the emergence of spatially localized domains characterized by distinct cell fates resulting from differential gene…
Spontaneous generation of persistent activity in diffusively coupled cellular assemblies
Ria Ghosh, Shakti N. Menon
The spontaneous generation of electrical activity underpins a number of essential physiological processes, and is observed even in tissues where specialized pacemaker cells have no…
Disorder in cellular packing can alter proliferation dynamics to regulate growth
Chandrashekar Kuyyamudi, Shakti N. Menon, Fernando Casares +1
Controlling growth via cell division is crucial in the development of higher organisms, and yet the mechanisms through which this is achieved, e.g., in epithelial tissue, is not ye…
Contact-mediated cellular communication supplements positional information to regulate spatial patterning during development
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
Development in multi-cellular organisms is marked by a high degree of spatial organization of the cells attaining distinct fates in the embryo. We show that receptor-ligand interac…
Uncovering the invariant structural organization of the human connectome
Anand Pathak, Shakti N. Menon, Sitabhra Sinha
In order to understand the complex cognitive functions of the human brain, it is essential to study the structural connectome, i.e., the wiring of different brain regions to each o…
The nonlinearity of interactions drives networks of neural oscillators to decoherence at strong coupling
Richa Tripathi, Shakti N. Menon, Sitabhra Sinha
While phase oscillators are often used to model neuronal populations, in contrast to the Kuramoto paradigm, strong interactions between brain areas can be associated with loss of s…
Mesoscopic architecture enhances communication across the Macaque connectome revealing structure-function correspondence in the brain
Anand Pathak, Shakti N. Menon, Sitabhra Sinha
Analyzing the brain in terms of organizational structures at intermediate scales provides an approach to negotiate the complexity arising from interactions between its large number…
Morphogen-regulated contact-mediated signaling between cells can drive the transitions underlying body segmentation in vertebrates
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
We propose a unified mechanism that reproduces the sequence of dynamical transitions observed during somitogenesis, the process of body segmentation during embryonic development, t…
Frequency gradients in heterogeneous oscillatory media can spatially localize self-organized wave sources that coordinate system-wide activity
Ria Ghosh, Pavithraa Seenivasan, Shakti N. Menon +4
Rhythmogenesis, which is critical for many biological functions, involves a transition to coherent activity through cell-cell communication. In the absence of centralized coordinat…
Is Life (or at least socio-economic aspects of it) just Spin and Games?
Shakti N. Menon, V. Sasidevan, Sitabhra Sinha
The enterprise of trying to explain different social and economic phenomena using concepts and ideas drawn from physics has a long history. Statistical mechanics, in particular, ha…
Lateral inhibition provides a unifying framework for spatiotemporal pattern formation in media comprising relaxation oscillators
R. Janaki, Shakti N. Menon, Rajeev Singh +1
The collective dynamics seen in a wide variety of chemical, biological and ecological systems involve interactions between relaxation oscillators that typically involve fast activa…
Non-associative learning in intra-cellular signaling networks
Tanmay Mitra, Shakti N. Menon, Sitabhra Sinha
Nonlinear systems driven by recurrent signals are known to exhibit complex dynamical responses which, in the physiological context, can have important functional consequences. One…
Milling and meandering: Flocking dynamics of stochastically interacting agents with a field of view
Trilochan Bagarti, Shakti N. Menon
We introduce a stochastic agent-based model for the flocking dynamics of self-propelled particles that exhibit velocity-alignment interactions with neighbours within their field of…
Emergent memory in cell signaling: Persistent adaptive dynamics in cascades can arise from the diversity of relaxation time-scales
Tanmay Mitra, Shakti N. Menon, Sitabhra Sinha
The mitogen-activated protein kinase (MAPK) signaling cascade, an evolutionarily conserved motif present in all eukaryotic cells, is involved in coordinating critical cell-fate dec…
Epidemic prevalence information on social networks mediates emergent collective outcomes in voluntary vaccine schemes
Anupama Sharma, Shakti N. Menon, V. Sasidevan +1
The success of a vaccination program is crucially dependent on its adoption by a critical fraction of the population, as the resulting herd immunity prevents future outbreaks of an…
A model for one-dimensional morphoelasticity and its application to fibroblast-populated collagen lattices
Shakti N. Menon, Cameron L. Hall, Scott W. McCue +1
The mechanical behaviour of solid biological tissues has long been described using models based on classical continuum mechanics. However, the classical continuum theories of elast…
Jamming in a lattice model of stochastically interacting agents with a field of view
Shakti N. Menon, Trilochan Bagarti, Abhijit Chakraborty
We study the collective dynamics of a lattice model of stochastically interacting agents with a weighted field of vision. We assume that agents preferentially interact with neighbo…
When the clock strikes: Modeling the relation between circadian rhythms and cardiac arrhythmias
Pavithraa Seenivasan, Shakti N. Menon, S. Sridhar +1
It has recently been observed that the occurrence of sudden cardiac death has a close statistical relationship with the time of day, viz., ventricular fibrillation is most likely t…