171 citations · 261 across the 9 of their papers we have counts for
9 papers
Gene expression noise accelerates the evolution of a biological oscillator
Yen Ting Lin, Nicolas E. Buchler
Gene expression is a biochemical process, where stochastic binding and un-binding events naturally generate fluctuations and cell-to-cell variability in gene dynamics. These fluctu…
Accelerated Bayesian inference of gene expression models from snapshots of single-cell transcripts
Yen Ting Lin, Nicolas E. Buchler
Understanding how stochastic gene expression is regulated in biological systems using snapshots of single-cell transcripts requires state-of-the-art methods of computational analys…
Efficient analysis of stochastic gene dynamics in the non-adiabatic regime using piecewise deterministic Markov processes
Yen Ting Lin, Nicolas E. Buchler
Single-cell experiments show that gene expression is stochastic and bursty, a feature that can emerge from slow switching between promoter states with different activities. One sou…
Role of DNA binding sites and slow unbinding kinetics in titration-based oscillators
Sargis Karapetyan, Nicolas E. Buchler
Genetic oscillators, such as circadian clocks, are constantly perturbed by molecular noise arising from the small number of molecules involved in gene regulation. One of the strong…
Designing sequential transcription logic: a simple genetic circuit for conditional memory
Georg Fritz, Nicolas E. Buchler, Terence Hwa +1
The ability to learn and respond to recurrent events depends on the capacity to remember transient biological signals received in the past. Moreover, it may be desirable to remembe…
Nonlinear Protein Degradation and the Function of Genetic Circuits
Nicolas E. Buchler, Ulrich Gerland, Terence Hwa
The functions of most genetic circuits require sufficient degrees of cooperativity in the circuit components. While mechanisms of cooperativity have been studied most extensively i…