3 papers
q-bio.PE2023
Using birth-death processes to infer tumor subpopulation structure from live-cell imaging drug screening data
C. Wu, E. B. Gunnarsson, E. M. Myklebust +6
Tumor heterogeneity is a complex and widely recognized trait that poses significant challenges in developing effective cancer therapies. In particular, many tumors harbor a variety…
math.OC2023
Modeling of mouse experiments suggests that optimal anti-hormonal treatment for breast cancer is diet-dependent
Tuğba Akman, Lisa M. Arendt, Jürgen Geisler +3
Estrogen receptor positive breast cancer is frequently treated with anti-hormonal treatment such as aromatase inhibitors (AI). Interestingly, a high body mass index has been shown…
q-bio.TO2016
Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico insights
J. C. L. Alfonso, A. Kohn-Luque, T. Stylianopoulos +3
There is an ongoing debate on the therapeutic potential of vaso-modulatory interventions against glioma invasion. Prominent vasculature-targeting therapies involve functional tumou…