6 citations · 12 across the 5 of their papers we have counts for
5 papers
A basket trial design based on power priors
Lukas Baumann, Lukas Sauer, Meinhard Kieser
In basket trials a treatment is investigated in several subgroups. They are primarily used in oncology in early clinical phases as single-arm trials with a binary endpoint. For the…
Analysis and sample size calculation within the responder stratified exponential survival model
Samuel Kilian, Johannes Krisam, Meinhard Kieser
The primary endpoint in oncology is usually overall survival, where differences between therapies may only be observable after many years. To avoid withholding of a promising thera…
Enhancing single-arm phase II trials by inclusion of matched control patients
Johannes Krisam, Dorothea Weber, Richard F. Schlenk +1
When a novel treatment has successfully passed phase I, different options to design subsequent phase II trials are available. One approach is a single-arm trial, comparing the resp…
Sample size calculation and blinded recalculation for analysis of covariance models with multiple random covariates
Georg Zimmermann, Meinhard Kieser, Arne Bathke
When testing for superiority in a parallel-group setting with a continuous outcome, adjusting for covariates (e.g., baseline measurements) is usually recommended, in order to reduc…
Optimal adaptive two-stage designs for single-arm trial with binary endpoint
Kevin Kunzmann, Meinhard Kieser
Minimizing the number of patients exposed to potentially harmful drugs in early onco logical trials is a major concern during planning. Adaptive designs account for the inherent un…