3 citations · 3 across the 1 of their papers we have counts for
3 papers
stat.ME2020★ 3 cited
Enhancing single-arm phase II trials by inclusion of matched control patients
Johannes Krisam, Dorothea Weber, Richard F. Schlenk +1
When a novel treatment has successfully passed phase I, different options to design subsequent phase II trials are available. One approach is a single-arm trial, comparing the resp…
stat.ME2018
Sample size calculation and blinded recalculation for analysis of covariance models with multiple random covariates
Georg Zimmermann, Meinhard Kieser, Arne Bathke
When testing for superiority in a parallel-group setting with a continuous outcome, adjusting for covariates (e.g., baseline measurements) is usually recommended, in order to reduc…
stat.AP2016
Optimal adaptive two-stage designs for single-arm trial with binary endpoint
Kevin Kunzmann, Meinhard Kieser
Minimizing the number of patients exposed to potentially harmful drugs in early onco logical trials is a major concern during planning. Adaptive designs account for the inherent un…