6 papers
Estimating the Distribution of Ratio of Paired Event Times in Phase II Oncology Trials
Li Chen, Mark Burkard, Jianrong Wu +2
With the rapid development of new anti-cancer agents which are cytostatic, new endpoints are needed to better measure treatment efficacy in phase II trials. For this purpose, Von H…
Weighted Mean Difference Statistics for Paired Data in Presence of Missing Values
Yuntong Li, Brent J. Shelton, William St Clair +5
Missing data is a common issue in many biomedical studies. Under a paired design, some subjects may have missing values in either one or both of the conditions due to loss of follo…
GEE-TGDR: A longitudinal feature selection algorithm and its application to lncRNA expression profiles for psoriasis patients treated with immune therapies
Suyan Tian, Chi Wang, Mayte Suarez-Farinas
With the fast evolution of high-throughput technology, longitudinal gene expression experiments have become affordable and increasingly common in biomedical fields. Generalized est…
Weighted SAMGSR: combining significance analysis of microarray-gene set reduction algorithm with pathway topology-based weights to select relevant genes
Suyan Tian, Howard H. Chang, Chi Wang
Introduction It has been demonstrated that a pathway-based feature selection method which incorporates biological information within pathways into the process of feature selection…
Feature selection for longitudinal microarray data by adapting a pathway analysis method
Suyan Tian, Chi Wang, Howard H. Chang
Introduction: Feature selection and gene set analysis are of increasing interest in bioinformatics. While these two approaches have been developed for different purposes, we descri…
No evidence of histology subtype-specific prognostic signatures among lung adenocarcinoma and squamous cell carcinoma patients at early stages
Suyan Tian, Chi Wang, Ming-Wen An
Background Non-small cell lung cancer (NSCLC) is the predominant histological type of lung cancer, accounting for up to 85% of cases. Disease stage is commonly used to determine ad…